Lucie MarandelResearcher


Since Jan 2014: INRA Researcher:UMR INRA-UPPA « Nutrition Metabolism Aquaculture ».

2012-2014: Post-doctoral research, Marie Curie ITN, Diagenode, Belgium (Marie Curie Fellowship).

2008-2011: PhD Student: INRA UR1037 LPGP, Rennes, France

2006-2008: Master in Biology, animal production and quality, University Rennes 1, France

2005-2008: Engineer in Agronomy, Ecole Nationale Supérieure Agronomique (ENSA-Agrocampus), France


Molecular biology, genomics, epigenetics, duplicated genomes

Thèmes de recherche

Epigenetic regulations induced by nutrients in the context of complex duplicated genomes of teleosts


Undergraduate (n=2 students); Master II (n=2 students) ; PhDs  (n=1 PhD students as co-director + 1 PhD for 1 year (Abroad PhDs coming for a training))


National project – 2 as leader (INRA and UPPA), European projects – involvement in Work Package: 2 projects (Aquaexcel 2020, ARRAINA), Involvement in projects with companies: DSM Nutritional Products, France.


Best, C., Ikert, H., Kostyniuk, D., Craig, P., Navarro-Martin, L., Marandel, L., Mennigen, J. A. (2018). Epigenetics in teleost fish : from molecular mechanisms to physiological phenotypes. Comparative Biochemistry and Physiology. Part B, Biochemistry and Molecular Biology, epub ahead of print. , DOI : 10.1016/j.cbpb.2018.01.006

Boonanuntanasarn, S., Kumkhong, S., Yoohat, K., Plagnes- Juan, E., Burel, C., Marandel, L., Panserat, S. (2018). Molecular responses of Nile tilapia ( Oreochromis niloticus ) to different levels of dietary carbohydrates. Aquaculture, 482, 117-123. , DOI : 10.1016/j.aquaculture.2017.09.032

Hu, H., Liu, J., Plagnes- Juan, E., Herman, A., Leguen, I., Goardon, L., Geurden, I., Panserat, S., Marandel, L. (2018). Programming of the glucose metabolism in rainbow trout juveniles after chronic hypoxia at hatching stage combined with a high dietary carbohydrate: Protein ratios intake at first-feeding. Aquaculture, 488, 1-8. , DOI : 10.1016/j.aquaculture.2018.01.015

Marandel, L., Gaudin, P., Gueraud, F., Glise, S., Herman, A., Plagnes- Juan, E., Véron, V., Panserat, S., Labonne, J. (2018). A reassessment of the carnivorous status of salmonids : hepatic glucokinase is expressed in wild fish in Kerguelen Islands. Science of the Total Environment, 612, 276-285. , DOI : 10.1016/j.scitotenv.2017.08.247

Liu, J., Plagnes- Juan, E., Geurden, I., Panserat, S., Marandel, L. (2017). Exposure to an acute hypoxic stimulus during early life affects the expression of glucose metabolism-related genes at first-feeding in trout. Scientific Reports, 7 (1), 1-11. , DOI : 10.1038/s41598-017-00458-4

Liu, J., Dias, K., Plagnes- Juan, E., Veron, V., Panserat, S., Marandel, L. (2017). Long-term programming effect of embryonic hypoxia exposure and high-carbohydrate diet at first feeding on glucose metabolism in juvenile rainbow trout. Journal of Experimental Biology, 220 (20), 3686-3694. , DOI : 10.1242/jeb.161406

Marandel, L., Panserat, S., Plagnes- Juan, E., Arbenoits, E., Soengas, J. L., Bobe, J. (2017). Evolutionary history of glucose-6-phosphatase encoding genes in vertebrate lineages: towards a better understanding of the functions of multiple duplicates. BMC Genomics, 18, 1-13. , DOI : 10.1186/s12864-017-3727-1

Panserat, S., Marandel, L., Geurden, I., Veron, V., Dias, K., Plagnes- Juan, E., Pegourie, G., Arbenoits, E., Santigosa, E., Weber, G., Verlhac Trichet, V. (2017). Muscle catabolic capacities and global hepatic epigenome are modified in juvenile rainbow trout fed different vitamin levels at first feeding. Aquaculture, 468, 515-523. , DOI : 10.1016/j.aquaculture.2016.11.021

Seiliez, I., Vélez, E. J., Lutfi, E., Dias, K., Plagnes- Juan, E., Marandel, L., Panserat, S., Geurden, I., Skiba-Cassy, S. (2017). Eating for two: Consequences of parental methionine nutrition on offspring metabolism in rainbow trout (Oncorhynchus mykiss). Aquaculture, 471, 80-91. , DOI : 10.1016/j.aquaculture.2017.01.010

Bobe, J., Marandel, L., Panserat, S., Boudinot, P., Bethelot, C., Quillet, E., Volff, J.-N., Genet, C., Jaillon, O., Roest Crollius, H., Guiguen, Y. (2016). The rainbow trout genome, an important landmark for aquaculture and genome evolution. In: Simon MacKenzie, Sissel Jentoft, Genomics in Aquaculture (p. 21-43). Amsterdam, NLD : Academic Press. 304 p., DOI : 10.1016/B978-0-12-801418-9.00002-0

Marandel, L., Dai, W. W., Panserat, S., Skiba-Cassy, S. (2016). The five glucose-6-phosphatase paralogous genes are differentially regulated by insulin alone or combined with high level of amino acids and/or glucose in trout hepatocytes. Molecular Biology Reports, 43 (4), 207-211. , DOI : 10.1007/s11033-016-3962-6

Marandel, L., Véron, V., Surget, A., Plagnes- Juan, E., Panserat, S. (2016). Glucose metabolism ontogenesis in rainbow trout (Oncorhynchus mykiss) in the light of the recently sequenced genome: new tools for intermediary metabolism programming. Journal of Experimental Biology, 219 (5), 734-743. , DOI : 10.1242/jeb.134304

Marandel, L., Lepais, O., Arbenoits, E., Veron, V., Dias, K., Zion, M., Panserat, S. (2016). Remodelling of the hepatic epigenetic landscape of glucose-intolerant rainbow trout (Oncorhynchus mykiss) by nutritional status and dietary carbohydrates. Scientific Reports, 6, 12 p. , DOI : 10.1038/srep32187

Marandel, L., Seiliez, I., Véron, V., Skiba Cassy, S., Panserat, S. (2015). New insights into the nutritional regulation of gluconeogenesis in carnivorous rainbow trout (Oncorhynchus mykiss): a gene duplication trail. Physiological Genomics, 47 (7), 253-263. , DOI : 10.1152/physiolgenomics.00026.2015

Seiliez, I., Froehlich, J. M., Marandel, L., Gabillard, J.-C., Biga, P. R. (2015). Evolutionary history and epigenetic regulation of the three paralogous pax7 genes in rainbow trout. Cell and Tissue Research, 359 (3), 715-727. , DOI : 10.1007/s00441-014-2060-0

Marandel, L., Labbé, C., Bobe, J., Jammes, H., Lareyre, J.-J., Le Bail, P.-Y. (2013). Do not put all teleosts in one net: focus on the sox2 and pou2 genes. Comparative Biochemistry and Physiology. Part B, Biochemistry and Molecular Biology, 164, 69-79. , DOI : 10.1016/j.cbpb.2012.10.005

Marandel, L., Labbé, C., Bobe, J., Le Bail, P.-Y. (2012). Evolutionary history of c-myc in teleosts and characterization of the duplicated c-myca genes in goldfish embryos. Molecular Reproduction and Development, 79 (2), 85-96. , DOI : 10.1002/mrd.22004

Marandel, L., Labbé, C., Bobe, J., Le Bail, P.-Y. (2012). nanog 5'-upstream sequence, DNA methylation, and expression in gametes and early embryo reveal striking differences between teleosts and mammals. Gene, 492, 130-137. , DOI : 10.1016/j.gene.2011.10.037

Depince, A., Marandel, L., Goardon, L., Le Bail, P.-Y., Labbé, C. (2011). Trout coelomic fluid suitability as Goldfish oocyte extender can be determined by a simple turbidity test. Theriogenology, 75 (9), 1755-1761. , DOI : 10.1016/j.theriogenology.2010.12.022