Stéphane Panserat

Responsabilities

• Scientific Leader of the UMR NuAGe INRA-Ifremer-Bordeaux 1 (2006-2009)  
• Deputy Director of the UR INRA NuMeA (Nutrition Metabolism Aquaculture) (2010-2014)
• Member of Executive Board for the FR MIRA (Milieux et Ressources Aquatiques) (>2015)
• Member of the Executive Board for the UMR NuMeA INRA-UPPA (>2017)
• Member of the « Commission Nationale des Universités: section 68 (biologie des organismes) » (>2013)

Skills

After obtaining a PhD in Human Genetics and Metabolism in Paris (University Paris 7 - Jussieu), I integrated the INRA fish nutrition laboratory 20 years ago to study the nutritional regulation of intermediary metabolism in fish. I am currently involved in the understanding of the glucose use in carnivorous rainbow trout (a glucose intolerant fish species) using different approaches (molecular biology, signaling, biochemistry, nutrition).

Research interests

My Main Research activities:

My researches have the objectives to improve the basic knowledge about intermediary metabolism and nutritional physiology in fish species with a focus on glucose metabolism.The impacts of my researches are for the aquaculture industry by trying to improve dietary carbohydrate use in fish through (i) development of adequate diet formulations based on the nutrient interactions, (ii) existence of fish lines showing different intermediary metabolism and (iii) development of the programming of metabolism after early biotic or abiotic stimuli. My favorite fish for my studies is rainbow trout but I am studying also other fish species such as Nile tilapia, European seabass, Atlantic salmon, gilthead seabream …

Other research activities:

Linked to my expertise in intermediary metabolism, I develop also some researches in collaboration with other colleagues about glucose metabolism and autophagy, glucose metabolism and epigenetics, energy metabolism and fish behavior (reproduction, migration, extreme conditions…), energy metabolism and growth hormone transgenic fish, nutritional programming in shrimps and ducks.

Supervision

Training :

• Licence/Master I (n=23 students)  ; 
• Master II (n=8 students) ;
• Thesis  (n=12 students as a director or co-director + 7 PhD) ;
• Post-doc (n=9 researchers)

Projects

Recent research projects:

• European project FP7 ARRAINA: advanced research initiatives for nutrition and aquaculture
• European project AQUAEXCELL2020: Aquaculture infrastructure for excellence in European fish research towards 2020
• FCT PEIXEROL: glycerol as alternative ingredient for fish feed – potential for aquaculture.
•  PHC SIAM : metabolic and molecular adaptation of Nile tilapia to dietary carbohydrates
• Research projects with companies: DSM; DIANA-AQUA; NeoVia

Publications

Articles in international scientific journals : 142 publications (including 12 reviews)

Books: 6 book chapters

Communications : 154 communications 72 posters and 81 oral presentations (including 19  invitations)

Web of Science – citation report (14/04/2018):

Recent scientific publications:

• Polakof S, Panserat S, Soengas J, Moon TW (2012) Glucose metabolism in fish : a review. J Comp Physiol B 182:1015–1045.
• Sam Kamalam BJ, MedaleF, KaushikS, Polakof S, Skiba-Cassy S, PanseratS (2012). Regulation of metabolism by dietary carbohydrates in two lines of rainbow trout divergently selected for muscle fat content. J exp Biol 215, 2567-2578.
• Geurden I, Mennigen J, Plagnes-Juan E, Veron V, Cerezo T., Mazurais D, Zambonino-Infante J, Gatesoupe J, Skiba-Cassy S, Panserat S (2014) High or low dietary carbohydrate : protein ratios during first-feeding affect glucose metabolism and intestinal microbiota in juvenile rainbow trout. J exp Biol  217 : 3396-3406.
• Seiliez, I Belghit, Y Gao, S Skiba-Cassy, K Dias, Cluzeaud M, Rémond D, Hafnaoui N, Salin B., Camougrand N, Panserat S (2016) Looking at the metabolic consequences of the colchicine-based in vivo autophagic flux assay. Autophagy 12(2): 343-356.
• Marandel L, Seiliez I, Veron V, Skiba-Cassy S, Panserat S (2015) New insigths into the nutritional regulation of gluconeogenesis in carnivorous rainbow trout: a gene duplication trail. Phys. Genomics 47: 253–263, 2015.
• Kamalam BJ, Medale F, Panserat S (2017) Utilisation of dietary carbohydrates in farmed fishes: New insights on influencing factors, biological limitations and future strategies. Aquaculture. 467:3-27.
• Marandel L, Lepais O, Arbenoits E, Véron V, Dias K, Zion M, Panserat S (2016) Remodelling of the hepatic epigenetic landscape of glucose intolerant rainbow trout (Oncorhynchus mykiss) by nutritional status and dietary carbohydrates. Sci Rep 6:32187.